Short Story ⬡ Biochemistry

Truth Taught by Equilibrium Constant

Learning the concept of chemical equilibrium, understanding that reactions never completely finish, and that equilibrium constants represent the 'character' of reactions.

  • #chemical equilibrium
  • #equilibrium constant
  • #reversible reactions
  • #dynamic equilibrium

"When does a reaction end?"

Kana asked a simple question.

Milia smiled. "Some reactions never end."

"Huh?"

Rei supplemented. "It's about chemical equilibrium. The reaction appears stopped, but is actually moving."

Kana was confused. "Stopped but moving?"

"Apparently stopped. But at the molecular level, constantly reacting," Milia explained.

Rei wrote an equation on the whiteboard.

"A ⇌ B"

"This double arrow is important. Reaction occurs both ways, A to B and B to A."

Kana copied into her notebook. "So, reversible reaction?"

"Yes. Many reactions are reversible."

Milia gave an example. "Water evaporation and condensation. Both occur simultaneously."

"In a sealed container, the number of evaporating and condensing molecules becomes equal," Rei continued.

"That's equilibrium?"

"Exactly. Called dynamic equilibrium. Not stationary."

Kana imagined. "Molecules going back and forth?"

"Beautiful description," Milia acknowledged.

Rei added an equation. "Equilibrium constant K is represented as [B]/[A]."

"Square brackets?"

"Concentration. The value of B's concentration at equilibrium divided by A's concentration."

Kana calculated. "If K is large?"

"B is abundant. Reaction shifts right," Milia answered.

"If K is small?"

"A is abundant. Reaction shifts left."

Rei supplemented. "If K is 1, A and B are roughly equal amounts."

Kana had a question. "Does K change?"

"Changes with temperature. Doesn't change with other conditions," Rei answered.

"What about pressure or concentration?"

"Equilibrium position changes, but K doesn't change."

Milia explained. "Le Chatelier's principle. The system moves to counteract changes."

"What if you increase concentration?"

"Equilibrium shifts to decrease that concentration."

Kana realized. "Reactions are smart."

"Just following physical laws," Rei corrected. "But it certainly looks autonomous."

Milia showed her tablet. "Enzyme reactions are also equilibria."

"But enzymes drive reactions forward, don't they?" Kana was surprised.

"Only accelerate speed. Don't change equilibrium position."

Rei drew a diagram. "Enzymes accelerate both forward and reverse reactions. The ratio doesn't change."

"So even with enzymes, reactions don't go completely forward?"

"Right. There's a limit determined by the equilibrium constant."

Kana thought. "But in living bodies, reactions do proceed, right?"

Milia laughed. "Good question. Living bodies aren't at equilibrium."

"What do you mean?"

"They constantly consume products. So equilibrium isn't reached."

Rei supplemented. "Metabolic pathways are chains of consecutive reactions. Each reaction's product becomes the substrate for the next."

"Removing products keeps the reaction going."

Kana understood. "Avoiding equilibrium."

"Life is a non-equilibrium system," Milia said quietly. "Equilibrium equals death."

Silence flowed.

Rei continued. "But equilibrium constant is still important. It tells us how easily reactions proceed."

"Reactions with large K proceed spontaneously."

"Reactions with small K require energy."

Kana summarized in her notebook. "Equilibrium constant = reaction's character."

"Perfect understanding," Milia praised.

"But," Kana added, "life can defy that character."

"Using ATP to drive unfavorable reactions."

Rei nodded. "Coupled reactions. Investing energy to shift equilibrium."

Kana was moved. "Life is amazing."

"Understanding equilibrium, then controlling it," Milia said.

"Gaining freedom within chemical laws."

Outside the window, clouds drifted. Appearing still, yet constantly moving. That's what equilibrium is like.